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    China’s pharmaceutical tablet packaging material choice principle

Western medicine tablets drug class is most varieties, one of the largest-selling pharmaceutical dosage forms. Packaging materials for pharmaceutical tablets direct contact with drugs, should therefore be considered a class of pharmaceutical packaging. Drugs are a special commodity, its efficacy and quality is directly related to human health and safety, the use of packaging materials and structures form in the need to ensure efficacy, it is also plays a drug used to ensure the reliability, convenience role, Therefore, as a pharmaceutical manufacturing enterprises in the selection of packaging materials, to understand the packaging materials, containers, some properties and characteristics in order to combine the special requirements of certain drugs, reasonable and accurate selection of medicinal packaging materials.

   Pharmaceutical tablet plastic bottles

    The 20th century, 80 years, as China continued from abroad of advanced pharmaceutical plastic bottle production line, with “plastic” generation “glass,” the prelude to the start began, from large volumes of glass bottles, brown bottles gradually withdraw this drug tablet packaging a field, replaced by a pharmaceutical plastic bottles, which are mainly non-toxic polymers such as PE, PP, PC, PET as the main raw material, the use of advanced plastic molding process and equipment for production of pharmaceutical plastic bottles, Main dress all kinds of oral tablets, capsules, capsule and liquid formulations of solid dosage forms of drugs.

    Medical plastic bottles greatest feature is the quality of light, non-friable, clean, beautiful, drug manufacturers do not have dry cleaning can be used directly. And its number of technical indicators and a large number of data indicate that its chemical resistance, water vapor permeability of excellent sealing performance, it completely loaded drugs can be played in the life of the security shield protection. Variety in the use of materials on the high-density polyethylene bottles (HDPE), polypropylene bottles (PP), polycarbonate bottles (PC), polyester bottles (PET), 20 century and the early 90s, foreign developed a blow molding bottle body of new material poly-dimethyl Diethyl naphthalene (PEN) plastic bottles, PET is more superior than its nature, its high strength, good heat resistance, resistance to ultraviolet radiation, carbon dioxide gas and oxygen barrier properties of excellent chemical resistance properties of Well, the use of PET more widely than, PEN material is a positive development at home and abroad in recent years, a new polyester resin, is also an excellent drug packaging materials, plastic bottles.

    Select bottles principles, since a number of pharmaceutical plastic bottle size, small dozen ml, large thousands of milliliters, some colorless, some transparent, various colors and shapes in various categories. The face of colorful plastic bottle market as pharmaceutical manufacturing enterprises in the selection of plastic bottles, the main grasp the following principles: first, choose plastic bottles main raw materials, auxiliary formula. Solid plastic bottles of product standards, respectively, the applicable provisions of the main raw material, and must comply with non-toxic, no odor, etc., available for use because there are a variety of the main raw materials, which need to be comprehensive performance of raw materials selection, general tablet use high-density polyethylene, polypropylene bottles, such as the need for transparency in the choice of PET bottles, such as pharmaceuticals require a higher barrier properties, and blocking light, opaque, then the choice of brown PET bottles, better barrier properties of PEN bottles. Liquid drug formulations in general use polypropylene bottles or PET bottles as the main raw material. Two, a bottle body and lid seal, water vapor permeability. Sealing and water vapor permeability of plastic bottles is a medical technology are two important indicators, they charge plays a crucial importance for the stability of the impact. 3, plastic bottles of product quality standards. From the production plant product quality standards in product quality can be analyzed to determine the pros and cons. Medical Plastic Bottle business should be to develop stricter than national standards, industry-standard enterprise standard. 4, the quality assurance system. Audits of suppliers has become an essential purchase an important part of plastic bottles. Through audits, can plant in software and hardware facilities, technical equipment, comprehensive level of quality, the right to make a comprehensive assessment. 5, plastic bottles charge stability and compatibility. Use plastic bottles, in particular, drug use new plastic bottles (or new materials, new processes) should be advanced packing and drug trials to examine the stability and plastic bottles charge compatibility between drug. Drugs, plastic bottle material inter-penetration, dissolution, adsorption, chemical reaction, denaturation must be determined by scientific testing.

    Pharmaceutical tablet blister packing

    Pharmaceutical blister packaging, also known as bubble eyes packaging, pharmaceutical tablets, compared with the bottle, blister packaging of the biggest advantages is the easy to carry, and can reduce the drugs to carry and use the process of pollution. But as often in patients with a view to medication, there is a single large dose, making blister packaging unit costs are significantly higher than that of bottled medicines, a number of pharmaceutical companies, often driving the price higher, high technology and new types of drug use bubble cover packaging are most common. Blister packaging material used mainly to “PTP” Medicinal hard aluminum foil and plastic film. Pharmaceutical aluminum foil is sealed in plastic film on the hard-sealing material, it hard for industrial use aluminum as a substrate, with non-toxic, corrosion-resistant, non-penetration, resistance heat, moisture, high-temperature sterilization may be blocking light and so on. Hard plastic sheet material is usually selected polyvinyl chloride (PVC), polyvinylidene chloride (PVDC), or composite materials. Their water, steam, light has good barrier properties.

    Pharmaceutical blister packaging material of choice for the basic principles of

    A, medicinal aluminum foil material selection issues and principles: demand-side before the introduction of PTP aluminum foil, first entered into procurement contracts with suppliers. In the contract technical requirements for products must specify: the product name, size (width and thickness requirements), printing color, aluminum foil roll arrangement of the direction and position of the text; aluminum foil structure, and adhesive coating weight, coating color availability requirements, packaging requirements.

    Second, use of medicinal rigid plastic or composite materials, the basic principles of film: ordinary tablet drugs, less demanding on the moisture resistant polyvinyl chloride that can be selected (PVC) rigid film. To have the moisture and antioxidant requirements, or require a longer shelf-life of drugs can choose a hard PET film, PP rigid film. Composite Hard films are: PVC and PVDC composite sheets (PVC / PVDC) or polyvinyl chloride and polyethylene and polyvinylidene chloride (PVC / PE / PVDC) composite films. Oral, suppository medicines can choose PVC and polyethylene composite film (PVC / PE). Select Hard-chip pharmaceutical blister packaging materials, the general procedure: a, according to the nature and shelf-life of drugs required to choose what kind of a hard polymer film, may consult the specific drug packaging material production enterprise technical experts, or material testing, we should fully taking into account the commonality of equipment, the appearance of novelty, of the lowest cost. b, carried out tests on the machine to determine the drug packaging materials, equipment and product quality and appearance of the applicability of the satisfaction. c, good stability, compatibility test, each drug will have to do, because a variety of drugs of a different nature. d, to the drug packaging materials, manufacturers of environmental, equipment, technology, quality management and other related elements of the review; and drug packaging materials manufacturer jointly identify drug packaging materials, raw materials, formulations and materials, packaging materials, product structure and standards, and finally signed the agreement.

    Pharmaceutical tablets with the aluminum bar compound film packing

    For some of the larger pharmaceutical tablet dosage forms or UV-sensitive, hygroscopicity strong, and require heat cold, and asked a long period and improve the packaging of pharmaceutical-grade tablets of choice, they use a bar composite film packaging, referred to as SP . It is the use of a two-tier medical strip packaging film (SP) film into tablets in the middle, separated by a certain distance between the units of medicine, in the strip packing machines of medicines around the two SP membranes inside the heat sealing seal between drugs pressure on the Indented, forming a unit package format (single package or rows form a small package). Strips in the strip packing machine continuous operation, particularly suitable for high-volume automated packaging. Dispensary, it can tear down the SP membrane can be Indented. Strip packaging film has a certain tensile strength and elongation, suitable for a variety of shapes and sizes of the drugs, and packaged close to built-in medicine, not easy to produce rupture and wrinkles. At present, more widespread use of the aluminum-plastic composite film, such as cellophane and aluminum foil and polyethylene (PT / AL / PE), polyester and aluminum foil and polyethylene (PET / AL / PE), or aluminum foil and plastic film in order to stick compounding or extrusion laminated composite mixture made from the grass-roots, printing layer, barrier layer, sealing layer, grass-roots outside, including the sealing layer, barrier layer, printing layer in the middle. Base materials require excellent mechanical properties, good glossy print, transparency, good barrier properties, safe non-toxic, and no sealing ability. Typical materials are polyester (PET), cellophane (PT), and with a PVDC coated cellophane. Barrier layer should be good on gas and moisture barrier properties, not by bacteria and microorganisms, excellent mechanical properties, there is a certain elongation, cold and heat, safe non-toxic material is a typical soft aluminum foil. However, this soft aluminum foil opaque, itself does not rust, shading and strong. If the bar needs to be transparent packaging films, they have to make use of PVDC barrier layer materials. PVDC barrier layer materials to make its most important feature is the gas, water vapor barrier properties superior. Sealing layer is the inner membrane strips, good sealing, while chemical stability and safety and health of the general use of low-density polyethylene material.

    Pharmaceutical companies the choice of drug packaging composite film, must be made by pharmaceutical properties (moisture, oxidation, Medicine Smell reservations, etc.) and shelf life is determined primarily on the basis of quality characteristics of pharmaceutical requirements, combined with characteristics of composite products choose to use, the following Medical composite membrane provides several features for reference: a, general composite membrane: Composite structure of polyester with aluminum foil and polyethylene (PET / AL / PE), is characterized by a good printing adaptability, good for drugs gas, the moisture barrier. b, medicinal easy tear strip composite films: composite structure in cellophane and polyethylene and aluminum foil compound (PT / PE / AL / PE). Characteristics are: easy to tear with a good, user-friendly access to products to consumers. Good gas, vapor barrier to ensure that the contents a longer shelf life. Applicable to effervescent agent, Paint, tablet capsules and other pharmaceutical packaging. c, paper plastic composite films: composite structure to paper and polyethylene and aluminum foil composite (paper / PE / AL / PE), characterized by: a good printing and good stiffness. The gas or water has good barrier properties can ensure a longer shelf life medicines.
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